You won't be able to redline 6th gear with that amount of power. I think a Whipple car with about 750rwhp should be able to do ~225-230mph in 5th with the redline raised to 7000, which is all I'd subject it to. I can't recall what the spreadsheet said the speed vs. rpm was at 7k, but it's somewhere in the 220s, but ballooning of the tires (hoosier) takes it a bit higher. I think on Goodyears it would be in that 225-230 range. I think 6th is probably just a bit to tall too pull 6th, and you run out of rpm in 5th.
Not that I know :wink but a car with more power than that has been verified at 232 mph and only stopped for lack of runway, so aero is no problem. I think the current twin turbo GT's would certainly pull 6th gear to over 260 mph given the space to do so. Tom Reichenbach always said the GT had the aero to do so without a problem, and given the ease with which a sub-1000rwhp clobbered 230mph, I don't foresee these cars with an addition 300-400rwhp maxing out the rpm in 6th.
At that point the concern is how long can the tires make it and the loads on the trans/engine.